Speaking: How to greet someone you know

"Hey John, how have you been?"
"Hi Bob, how are you?"
"Hi Nancy, what have you been up to?"
"Andy, it's been a long time, how are you man?"

If you meet someone unexpectedly, you can say,
"Hey Jack, it's good to see you. What are you doing here?"
or
"What a surprise. I haven't seen you in a long time. How have you been?"

If you see the person at a restaurant, you can say, "Do you come to this restaurant often?"
Or at the movie theatre, "What movie did you come to see?"

Appropriate responses:

"Hi Steve, my name is Mike. It is nice to meet you as well."

"I heard a lot about you from John. He had a lot of good things to say."

"Wow. How long has it been? It seems like more than a year. I'm doing pretty well. How about you?"

A typical response to this type of greeting is simple.

"Not too bad."

If asked what you have been up to, you can respond with, "Same ole same ole." Or, "The same as usual."

Here are some other example responses.

"I'm pretty busy at work these days, but otherwise, everything is great."
"I'm doing very well."
"I finally have some free time. I just finished taking a big examination, and I'm so relieved that I'm done with it."

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Source: http://www.talkenglish.com/LessonDetails.aspx?ALID=521